Some of the active ingredients documented, researched, and verified in graviola are a group of Annonaceous Acetogenins which are only found in the Annonaceae family to which graviola belongs. These phytochemicals are being researched and patented around the world for their active biological properties and potential uses. Many bioactive compounds and phytochemicals have been found in Graviola, as scientists have been studying its properties since the 1940s. Its many uses in natural medicine have been validated by scientific research. Several studies by different researchers demonstrated that the bark as well as the leaves had hypotensive, antispasmodic, anticonvulsant, vasodilator, smooth-muscle relaxant, and cardiodepressant activities in animals. Researchers verified Graviola leaf's hypotensive properties in rats again in 1991. Several studies over the years have demonstrated that leaf, bark, root, stem, and seed extracts of Graviola are antibacterial in vitro against numerous pathogens, and that the bark has anti-fungal properties. Graviola seeds demonstrated active anti-parasitic properties in a 1991 study, and a leaf extract showed to be active against malaria in two other studies (in 1990 and 1993). The leaves, root, and seeds of Graviola demonstrated insecticide properties, with the seeds demonstrating strong insecticidal activity in an early 1940 study.
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